RRx-001, a downregulator of the CD47- SIRPα checkpoint pathway, does not cause anemia or thrombocytopenia-Reference-Cited by-同舟云学术

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RRx-001, a downregulator of the CD47- SIRPα checkpoint pathway, does not cause anemia or thrombocytopenia

Published:2021-01-22 Issue:4 Volume:17 Page:355-357
ISSN:1742-5255
Container-title:Expert Opinion on Drug Metabolism & Toxicology
language:en
Short-container-title:Expert Opinion on Drug Metabolism & Toxicology

Author:

Oronsky Bryan¹,Cabrales Pedro²,Caroen Scott¹,Guo Xiaoning³,Scribner Curtis¹,Oronsky Arnold⁴,Reid Tony R.¹

Affiliation:

1. Clinical Department, EpicentRx, Inc, La Jolla, CA, USA

2. Department of Bioengineering, University of California San Diego, La Jolla, CA, USA

3. Clinical Department, SciClone Pharmaceuticals Co. Ltd, Shanghai, China

4. InterWest Partners, Los Altos, CA, USA

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/17425255.2021.1876025

Reference25 articles.

1. IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition

2. A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers.

3. REPLATINUM Phase III randomized study: RRx-001 + platinum doublet versus platinum doublet in third-line small cell lung cancer

4. The small-cell lung cancer drug market

5. Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study

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1. Preclinical testing of RRx-001 in mouse models of experimental endometriosis reveals promising therapeutic impacts;2024-08-12

2. Environmentally responsive hydrogel promotes vascular normalization to enhance STING anti-tumor immunity;Journal of Controlled Release;2024-08

3. NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion;Proceedings of the National Academy of Sciences;2024-03-28

4. Deciphering the role of CD47 in cancer immunotherapy;Journal of Advanced Research;2023-10

5. New hope for tumor immunotherapy: the macrophage-related “do not eat me” signaling pathway;Frontiers in Pharmacology;2023-07-06

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