Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study

Author:

Reid Tony,Oronsky Bryan,Scicinski Jan,Scribner Curt L,Knox Susan J,Ning Shoucheng,Peehl Donna M,Korn Ron,Stirn Meaghan,Carter Corey A,Oronsky Arnold,Taylor Michael J,Fitch William L,Cabrales Pedro,Kim Michelle M,Burris Howard A,Lao Christopher D,Abrouk Nacer E D,Fanger Gary R,Infante Jeffrey R

Publisher

Elsevier BV

Subject

Oncology

Reference39 articles.

1. Evolution of acquired resistance to anti-cancer therapy;Foo;J Theor Biol,2014

2. Gene silencing in cancer in association with promoter hypermethylation;Herman;N Engl J Med,2003

3. Cabrales P, Reid T, Oronsky B et al. RRx-001 an EXO-based epigenetic anti-cancer agent in phase 2 clinical trials. ISEV2014 Educational Event; San Diego, CA, USA; Oct 26, 2014.

4. Dinitroazetidines are a novel class of anticancer agents and hypoxia-activated radiation sensitizers developed from highly energetic materials;Ning;Cancer Res,2012

5. Anti-myeloma activity of a novel free radical inducer RRx-001;Sharma Das;Blood,2014

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