Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates-Reference-Cited by-同舟云学术

Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates

Published:2007-06 Issue:6 Volume:37 Page:618-634
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Umehara K.-I.,Iwatsubo T.,Noguchi K.,Kamimura H.

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.1080/00498250701397705

Reference34 articles.

1. Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1

2. Differential Substrate and Inhibitory Activities of Ranitidine and Famotidine toward Human Organic Cation Transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)

3. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

4. The organic cation transporter OCT2 mediates the uptake ofβ-adrenoceptor antagonists across the apical membrane of renal LLC-PK1cell monolayers

5. Cloning and Characterization of Two Human Polyspecific Organic Cation Transporters

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