CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes-Reference-Cited by-同舟云学术

CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes

Published:2003-01 Issue:2 Volume:33 Page:141-151
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Hu Y.,Dehal S. S.,Hynd G.,Jones G. B.,Kupfer D.

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

http://www.tandfonline.com/doi/pdf/10.1080/0049825021000042733

Reference26 articles.

1. α-Hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro

2. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues.

3. HYDROXYLATION OF TRANS-?1-TETRAHYDROCANNABINOL BY HEPATIC MICROSOMAL OXYGENASE

4. Breast cancer chemoprevention tamoxifen: Current issues and future prospective

5. Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

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