Actinomycin D synergistically enhances the cytotoxicity of CDDP on KB cells by activating P53 via decreasing P53

Actinomycin D synergistically enhances the cytotoxicity of CDDP on KB cells by activating P53 via decreasing P53–MDM2 complex

Published:2017-04-25 Issue:6 Volume:19 Page:630-643
ISSN:1028-6020
Container-title:Journal of Asian Natural Products Research
language:en
Short-container-title:Journal of Asian Natural Products Research

Author:

Wang Lin¹,Pang Xiao-Cong¹,Yu Zi-Ru¹,Yang Sheng-Qian¹,Liu Ai-Lin¹,Wang Jin-Hua¹,Du Guan-Hua¹

Affiliation:

1. Beijing Key Laboratory of Drug Targets Research and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

Funder

National Science and Technology

National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

Publisher

Informa UK Limited

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,General Medicine,Analytical Chemistry

Link

https://www.tandfonline.com/doi/pdf/10.1080/10286020.2017.1318853

Reference25 articles.

1. International Journal of Cancer

2. Specific activation of the p53 pathway by low dose actinomycin D: A new route to p53 based cyclotherapy

3. 5,6-Dihydroxy-3,7,4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells

4. An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells

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1. Actinomycin D synergizes with Doxorubicin in triple-negative breast cancer by inducing P53-dependent cell apoptosis;Carcinogenesis;2023-11-24

2. Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway;Scientific Reports;2019-12

3. Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3;The Analyst;2019