An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells
Author:
Publisher
Informa UK Limited
Subject
Cell Biology,Developmental Biology,Molecular Biology
Link
http://www.tandfonline.com/doi/pdf/10.4161/cc.20254
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1. Cyclotherapy: Protection of Normal Cells and Unshielding of Cancer Cells
2. Pharmacological manipulation of the cell cycle and metabolism to protect normal tissues against conventional anticancer drugs
3. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
4. Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs
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