AURKB promotes tumorigenesis and carboplatin resistance by regulating the ERK pathway in neuroblastoma cells

Author:

Yang Yonglin1,Sheng Ying2,Sun Dahong2,Sun Jilan3,Li Li4,Sun Lizhi5

Affiliation:

1. Department of Neurosurgery, People’s Hospital of Rizhao, Rizhao 276800, China;

2. Department of Pediatrics, the Third People’s Hospital of Qingdao, Qingdao 266041, China;

3. Sterilization Supply Room, the People’s Hospital of Zhangqiu Area, Jinan 250200, China;

4. Department of Neurosurgery, the People’s Hospital of Zhangqiu Area, Jinan 250200, China;

5. Department of Medical Laboratory Diagnosis Center, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, Shandong, China

Publisher

Informa UK Limited

Subject

General Medicine,General Neuroscience

Reference14 articles.

1. Borges KS, Castro-Gamero AM, Moreno DA, da Silva Silveira V, Brassesco MS, de Paula Queiroz RG, de Oliveira HF, Carlotti CG, Jr., Scrideli CA, Tone LG: Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells. Journal of cancer research and clinical oncology 2012, 138(3):405-414.

2. Alafate W, Wang M, Zuo J, Wu W, Sun L, Liu C, Xie W, Wang J: Targeting Aurora kinase B attenuates chemoresistance in glioblastoma via a synergistic manner with temozolomide. Pathology, research and practice 2019, 215(11):152617.

3. Yang J, Ikezoe T, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y, Komatsu N, Bandobashi K, Togitani K, Koeffler HP et al: AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 2007, 110(6):2034-2040.

4. Spartà AM, Bressanin D, Chiarini F, Lonetti A, Cappellini A, Evangelisti C, Evangelisti C, Melchionda F, Pession A, Bertaina A et al: Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia. Cell cycle (Georgetown, Tex) 2014, 13(14):2237-2247.

5. Smith SL, Bowers NL, Betticher DC, Gautschi O, Ratschiller D, Hoban PR, Booton R, Santibáñez-Koref MF, Heighway J: Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability. British journal of cancer 2005, 93(6):719-729.

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