Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: Application to (R)-dimethindene occupancy of central histamine H1receptors-Reference-Cited by-同舟云学术

Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: Application to (R)-dimethindene occupancy of central histamine H1receptors

Published:2009-04 Issue:2 Volume:29 Page:84-93
ISSN:1079-9893
Container-title:Journal of Receptors and Signal Transduction
language:en
Short-container-title:Journal of Receptors and Signal Transduction

Author:

Malany Siobhan,Hernandez Lisa M.,Smith William F.,Crowe Paul D.,Hoare Sam R. J.

Publisher

Informa UK Limited

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://www.tandfonline.com/doi/pdf/10.1080/10799890902721339

Reference18 articles.

1. Drug–target residence time and its implications for lead optimization

2. Models and methods for studying insurmountable antagonism

3. Slow antagonist dissociation and long-lasting in vivo receptor protection

4. Analysis of ligand binding to receptors by competition kinetics. Application to muscarinic antagonists in rat brain cortex.

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