Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity

Author:

Jia Liqiu1,Weng Shufeng2,Wu Jing1,Tian Xiangxiang34,Zhang Yifan34,Wang Xuyang1,Wang Jing35,Yan Dongmei5,Wang Wanhai4,Fang Fang3,Zhu Zhaoqin3,Qiu Chao6,Zhang Wenhong1278,Xu Ying2,Wan Yanmin129ORCID

Affiliation:

1. Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China

2. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China

3. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

4. Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, Zhengzhou, China

5. Department of Immunology, School of Basic Medical, Jiamusi University, Jiamusi, China

6. Institutes of Biomedical Sciences & Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China

7. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China

8. Key Laboratory of Medical Molecular Virology (MOE/MOH), Shanghai Medical College, Fudan University, Shanghai, China

9. Department of Radiology, Shanghai Public Health Clinical Center, Shanghai, China

Funder

National Natural Science Foundation of China

major project of Study on Pathogenesis and Epidemic Prevention Technology System by the Ministry of Science and Technology of China

Science and Technology Commission of Shanghai Municipality

Shanghai Municipal Science and Technology Major Project

Shanghai Science and Technology Committee

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Gastroenterology,Microbiology

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