Helicase-primase inhibitors from Medshine Discovery Inc. (WO2018/127207 and WO2020/007355) for the treatment of herpes simplex virus infections – structure proposal for Phaeno Therapeutics drug candidate HN0037
Author:
Affiliation:
1. Innovative Molecules GmbH, München, Germany
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/13543776.2022.2113873
Reference34 articles.
1. Antiviral Therapies for Herpesviruses: Current Agents and New Directions
2. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease
3. The DNA helicase–primase complex as a target for herpes viral infection
4. Amenamevir, a novel helicase-primase inhibitor, for treatment of herpes zoster: A randomized, double-blind, valaciclovir-controlled phase 3 study
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1. Helicase-primase inhibitors for the treatment of herpes simplex virus infections – patent evaluation of WO2023/225162 from gilead sciences inc;Expert Opinion on Therapeutic Patents;2024-09-11
2. Replacement of sulfonamide by sulfoximine within a helicase-primase inhibitor with restricted flexibility;Bioorganic & Medicinal Chemistry Letters;2024-07
3. Therapeutic strategies for COVID-19: progress and lessons learned;Nature Reviews Drug Discovery;2023-04-19
4. Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX Systems;International Journal of Molecular Sciences;2022-11-27
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