Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction
Author:
Affiliation:
1. Institute for Cardiovascular and Metabolic Research, University of Reading, School of Biological Sciences, Reading, UK
2. Department of Microbiology Immunology and Pathology, Colorado State University, Fort Collins, CO, USA
Funder
British Heart Foundation
Publisher
Informa UK Limited
Subject
Hematology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/09537104.2018.1514107
Reference49 articles.
1. Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
2. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial
3. A Case of Intracranial Hemorrhage Caused by Combined Dabrafenib and Trametinib Therapy for Metastatic Melanoma
4. Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas
5. Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)
Cited by 8 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Intracranial hemorrhage caused by dabrafenib and trametinib therapy for metastatic melanoma;Melanoma Research;2024-04-05
2. MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ;Nature Communications;2023-04-06
3. Characterization of the impact of immune checkpoint inhibitors on platelet activation and aggregation;Immunobiology;2023-01
4. Allosteric crosstalk in modular proteins: Function fine-tuning and drug design;Computational and Structural Biotechnology Journal;2023
5. Outcomes of Patients with Metastatic Melanoma—A Single-Institution Retrospective Analysis;Cancers;2022-03-25
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3