Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)-Reference-Cited by-同舟云学术

Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

Published:2012-04-12 Issue:5 Volume:3 Page:416-421
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Rice Kenneth D.¹,Aay Naing¹,Anand Neel K.¹,Blazey Charles M.¹,Bowles Owen J.¹,Bussenius Joerg¹,Costanzo Simona¹,Curtis Jeffry K.¹,Defina Steven C.¹,Dubenko Larisa¹,Engst Stefan¹,Joshi Anagha A.¹,Kennedy Abigail R.¹,Kim Angie I.¹,Koltun Elena S.¹,Lougheed Julie C.¹,Manalo Jean-Claire L.¹,Martini Jean-Francois¹,Nuss John M.¹,Peto Csaba J.¹,Tsang Tsze H.¹,Yu Peiwen¹,Johnston Stuart¹

Affiliation:

1. Exelixis Inc., 210 East Grand Avenue, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300049d

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