Microfluidic whole blood testing of platelet response to pharmacological agents
Author:
Affiliation:
1. Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA
2. Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA
Funder
National Institutes of Health
Publisher
Informa UK Limited
Subject
Hematology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/09537104.2016.1268254
Reference25 articles.
1. Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network
2. Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse
3. Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient
4. P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions
5. Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technology
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