1. a Field of Drug Discovery Research, Faculty of Advanced Life Science and Graduate School of Life Science , Hokkaido University , N21, W11, Kita-ku, Sapporo , 001-0021 , Japan
2. b Medicinal Chemistry Pharmaceuticals , LLC, 1-715, N7, W4, Kita-ku, Sapporo , 060-0807 , Japan
3. c Division of Environmental Materials Science, Graduate School of Environmental Science , Hokkaido University , N10, W5, Kita-ku, Sapporo , 060-0810 , Japan