Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L

Author:

de Medeiros Amanda Fernandes1ORCID,de Souza Beatriz Blenda Pinheiro23ORCID,Coutinho Lucas Pinheiro4ORCID,Murad Aline Melro3ORCID,dos Santos Paula Ivani Medeiros5ORCID,Monteiro Norberto de Kássio Vieira6ORCID,Santos Elizeu Antunes dos178ORCID,Maciel Bruna Leal Lima910ORCID,de Araújo Morais Ana Heloneida1910ORCID

Affiliation:

1. Postgraduate Biochemistry Program, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil

2. Postgraduate Biological Molecular, Institute of Biological Sciences, University of Brasília, Brasília, Brazil

3. Laboratory of Mass Spectometry-LEM, Embrapa Genetic Resources and Biotechnology, Brasília, Brazil

4. Chemistry Course, Science Center, Federal University of Ceará, Fortaleza, Brazil

5. Federal Institute of Education, Science and Technology of Rio Grande do Norte, Brazil

6. Analytical Chemistry and physical Chemistry Department, Science Center, Federal University of Ceará, Fortaleza, Brazil

7. Department of Biochemistry, Biosciences Center, Federal University of Rio Grande, Natal, Brazil

8. Tropical Medicine Institute, Federal University of Rio Grande do Norte, Natal, Brazil

9. Postgraduate Nutrition Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil

10. Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Cientítico e Tecnológico

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference50 articles.

1. Protein Inhibitors of Proteinases

2. Serine peptidases: Classification, structure and function

3. Serine proteases

4. Santos EA, Oliveira AS, Arajo Rablo LM, Ferreira A, Arajo Morais AH. Affinity chromatography as a key tool to purify protein protease inhibitors from plants. In: Affinity chromatography. InTech; 2012. p. 35. http://www.intechopen.com/books/affinity-chromatography/affinity-chromatography-as-a-key-tool-to-purify-protease-inhibitors-from-plants.

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