Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from <i>β</i> -elemene scaffold-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β -elemene scaffold

Published:2023-04-04 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Gao Yuan¹²,Duan Jilong²,Dang Xiawen²,Yuan Yinghui²,Wang Yu³,He Xingrui²,Bai Renren²,Ye Xiang-Yang²,Xie Tian¹²

Affiliation:

1. Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

2. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China

3. Research and Development, Dalian HolleyKingkong Pharmaceutical Co. Ltd, Liaoning, China

Funder

National Natural Science Foundation of China

Hangzhou Normal University Startup Fund

Ministry of Science and Technology of China

Hangzhou City “115” Plan to Introduce Overseas Intelligence Projects

General Scientific Research Project of Department of Education of Zhejiang Province

Science and Technology Department of Zhejiang Province

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2195991

Reference48 articles.

1. Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review

2. Xie T. Elemene antitumor drugs: molecular compatibility theory and its applications in new drug development and clinical practice. 1st ed. Amsterdam: Elsevier; 2022.

3. Inactivation of Stat3 and crosstalk of miRNA155-5p and FOXO3a contribute to the induction of IGFBP1 expression by beta-elemene in human lung cancer

4. Anti-tumor effect and mechanistic study of elemene on pancreatic carcinoma

5. β-elemene increases the sensitivity of gastric cancer cells to TRAIL by promoting the formation of DISC in lipid rafts

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