Design, Synthesis, and Structure–Activity Relationship of Novel Pyridazinone-Based PARP7/HDACs Dual Inhibitors for Elucidating the Relationship between Antitumor Immunity and HDACs Inhibition-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure–Activity Relationship of Novel Pyridazinone-Based PARP7/HDACs Dual Inhibitors for Elucidating the Relationship between Antitumor Immunity and HDACs Inhibition

Published:2024-03-08 Issue:6 Volume:67 Page:4950-4976
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Duan Ji-Long¹²,Wang Chen-Chen³,Yuan Yinghui¹²,Hui Zi¹²^ORCID,Zhang Hang⁴,Mao Nian-Dong³,Zhang Pengpeng¹²,Sun Bowen¹²,Lin Jing⁵,Zhang Zishuo⁴,Gao Yuan¹⁶,Xie Tian¹²,Ye Xiang-Yang¹²^ORCID

Affiliation:

1. School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China

2. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China

3. College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China

4. School of Basic Medical Science, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China

5. Drug Discovery, Hangzhou Haolu Pharma Ltd. Co., Hangzhou, Zhejiang 311121, China

6. Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200000, China

Funder

High-end Foreign Experts Recruitment Plan of China

Science and Technology Department of Zhejiang Province

Medical Science and Technology Project of Zhejiang Province

Department of Education of Zhejiang Province

Hangzhou?s ?115? plan to introduce overseas intelligence projects

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00090

Reference36 articles.

1. Cancer cell cycle dystopia: heterogeneity, plasticity, and therapy

2. PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

3. Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight

4. Chromatin Structure: A Repeating Unit of Histones and DNA

5. Histones, histone chaperones and nucleosome assembly

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