Design, synthesis, and biological evaluation of novel androst-17β-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists-Reference-Cited by-同舟云学术

Design, synthesis, and biological evaluation of novel androst-17β-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists

Published:2019-01-01 Issue:1 Volume:34 Page:1597-1606
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Lao Kejing¹²³,Xun Guoliang⁴,Gou Xingchun¹,Xiang Hua²³

Affiliation:

1. Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Brain Disorders, Xi’an Medical University, Xi'an, PR China;

2. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing, PR China;

3. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, PR China;

4. Abbisko Therapeutics Co Ltd, Shanghai, PR China

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2019.1654469

Reference19 articles.

1. Cancer statistics, 2019

2. Androgens and androgen receptor signaling in prostate tumorigenesis

3. Androgen receptor antagonists for prostate cancer therapy

4. Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

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