Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site-Reference-Cited by-同舟云学术

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site

Published:2016-07-19 Issue:sup4 Volume:31 Page:170-175
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Masini Tiziana¹,Birkaya Barbara²,van Dijk Simon¹,Mondal Milon¹,Hekelaar Johan³,Jäger Manuel¹,Terwisscha van Scheltinga Anke C.³,Patel Mulchand S.²,Hirsch Anna K. H.¹,Moman Edelmiro⁴⁵

Affiliation:

1. Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands,

2. Department of Biochemistry, School of Medicine and Biomedical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, USA,

3. Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands,

4. Molecular Design Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland, and

5. RCSI Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2016.1201812

Reference37 articles.

1. How cancer metabolism is tuned for proliferation and vulnerable to disruption

2. Regulation of cancer cell metabolism

3. Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

4. Targeting mitochondria metabolism for cancer therapy

5. Cancer's Molecular Sweet Tooth and the Warburg Effect: Figure 1.

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, Biological, and Molecular Docking Studies on 4,5,6,7-Tetrahydrobenzo[b]thiophene Derivatives and Their Nanoparticles Targeting Colorectal Cancer;ACS Omega;2021-10-25

2. Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2021-08

3. Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors;Journal of Medicinal Chemistry;2019-08-30

4. Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer;JNCI: Journal of the National Cancer Institute;2017-06-19