Design and synthesis of novel rigid dibenzo[ b,f ]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

Author:

El-Behairy Mohammed Farrag1ORCID,Abd-Allah Walaa Hamada2,Khalifa Mohamed M.3ORCID,Nafie Mohamed S.4ORCID,Saleh Mohamed A.56,Abdel-Maksoud Mohammed S.7,Al-Warhi Tarfah8,Eldehna Wagdy M.9ORCID,Al‐Karmalawy Ahmed A.10ORCID

Affiliation:

1. Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufiya, Egypt

2. Pharmaceutical Chemistry Department, Collage of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt

3. Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

4. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

5. Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, The United Arab Emirates

6. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

7. Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), Giza, Egypt

8. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

9. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

10. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt

Funder

The Deanship of Scientific Research at Princess Nourah Bint Abdulrahman University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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