Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, <i>in vitro</i> assays, and <i>in silico</i> studies-Reference-Cited by-同舟云学术

Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies

Published:2022-09-12 Issue:1 Volume:37 Page:2489-2511
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Saad Mohamed H.¹,El-Moselhy Tarek F.²,S, El-Din Nabaweya²,Mehany Ahmed B. M.³^ORCID,Belal Amany⁴⁵^ORCID,Abourehab Mohammed A. S.⁶⁷^ORCID,Tawfik Haytham O.²^ORCID,El-Hamamsy Mervat H.²

Affiliation:

1. The Egyptian Ministry of Health, Tanta, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt

3. Zoology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

4. Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt

5. Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia

6. Department of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

7. Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia, Egypt

Funder

Umm Al-Qura University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2120478

Reference81 articles.

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4. The multi-molecular mechanisms of tumor-targeted drug resistance in precision medicine

5. EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment

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