Novel N -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

Author:

Haffez Hesham12ORCID,Elsayed Nosaiba A.3,Ahmed Marwa F.3,Fatahala Samar S.4,Khaleel Eman F.5,Badi Rehab Mustafa5,Elkaeed Eslam B.6,El Hassab Mahmoud A.7,Hammad Sherif F.38,Eldehna Wagdy M.9ORCID,Masurier Nicolas10ORCID,El-Haggar Radwan3ORCID

Affiliation:

1. Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Ain Helwan, Egypt

2. Center of Scientific Excellence “Helwan Structural Biology Research, (HSBR)”, Helwan University, Cairo, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Ain Helwan, Egypt

4. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

5. Department of Medical Physiology, College of Medicine, King Khalid University, Asir, Saudi Arabia

6. Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia

7. Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt

8. Medicinal Chemistry Department, PharmD Program, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, Egypt Alexandria

9. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

10. Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, France

Funder

Deanship of Scientific Research at King Khalid University

Scientific Research Fund - Vice president′s office for Graduate Studies and Research - Helwan University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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