Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors <i>via</i> upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages-Reference-Cited by-同舟云学术

Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

Published:2023-08-09 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Ghany Lina M. A. Abdel¹,Beshay Botros Y.²,Youssef Moustafa Amal M.³,Maghrabi Ali Hassan Ahmed⁴,Ali Eman Hussain Khalifa⁵,Saleem Rasha Mohammed⁶,Zaki Islam⁷,Ryad Noha⁸

Affiliation:

1. Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt

2. Pharmaceutical Sciences (Pharmaceutical Chemistry) Department, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt

3. Chemistry Department, College of Science, Port Said University, Port Said, Egypt

4. Department of Biology, Umm Al-Qura University, Makkah, Saudi Arabia

5. Department of Laboratory Medicine, Al-Baha University, Al-Baha, Saudi Arabia

6. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia

7. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said, Egypt

8. Pharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2243551

Reference43 articles.

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2. Mechanisms of the inflammatory response

3. Chronic Diseases Caused by Chronic Inflammation Require Chronic Treatment: Anti-inflammatory Role of Dietary Spices

4. Curcumin as an Alternative Epigenetic Modulator: Mechanism of Action and Potential Effects

5. Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications

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