New spiro-indeno[1,2- <i>b</i> ]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights-Reference-Cited by-同舟云学术

New spiro-indeno[1,2- b ]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights

Published:2023-11-23 Issue:1 Volume:38 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Barakat Assem¹^ORCID,Alshahrani Saeed¹^ORCID,Al-Majid Abdullah Mohammed¹^ORCID,Alamary Abdullah Saleh¹^ORCID,Haukka Matti²^ORCID,Abu-Serie Marwa M.³^ORCID,Domingo Luis R.⁴^ORCID,Ashraf Sajda⁵^ORCID,Ul-Haq Zaheer⁵^ORCID,Nafie Mohamed S.⁶⁷^ORCID,Teleb Mohamed⁸^ORCID

Affiliation:

1. Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

2. Department of Chemistry, University of Jyväskylä, Jyväskylä, Finland

3. Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt

4. Department of Organic Chemistry, University of Valencia, Burjassot, Valencia, Spain

5. Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

6. Department of Chemistry, College of Sciences, University of Sharjah, Sharjah, UAE

7. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

8. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Funder

King Saud University, Riyadh, Saudi Arabia

(AEI/FEDER, UE), Ministerio de Ciencias, Innovación y Universidades of the Spanish Government

(AEI/FEDER, UE), Ministerio de Ciencias, Inno-vación y Universidades of the Spanish Government

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2023.2281260

Reference70 articles.

1. Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

2. Proliferation of cancer cells despite CDK2 inhibition

3. Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression

4. Anti-Cancer Activity of Catechin against A549 Lung Carcinoma Cells by Induction of Cyclin Kinase Inhibitor p21 and Suppression of Cyclin E1 and P–AKT

5. Identification of the prognostic and therapeutic values of cyclin E1 (CCNE1) gene expression in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma: A database mining approach

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