Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies-Reference-Cited by-同舟云学术

Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies

Published:2024 Issue:8 Volume:15 Page:2937-2958
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Islam Mohammad Shahidul¹^ORCID,Al-Jassas Refaah M.¹,Al-Majid Abdullah Mohammed¹,Haukka Matti²^ORCID,Nafie Mohamed S.³⁴^ORCID,Abu-Serie Marwa M.⁵,Teleb Mohamed⁶,El-Yazbi Amira⁷^ORCID,Alayyaf Abdul Majeed Abdullah¹,Barakat Assem¹^ORCID,Shaaban Marwa M.⁶

Affiliation:

1. Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia

2. Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014 Jyväskylä, Finland

3. Department of Chemistry, College of Sciences, University of Sharjah, Sharjah (P.O. Box 27272), United Arab Emirates

4. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt

5. Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt

6. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt

7. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Abstract

A new spirooxindole was designed, synthesized and characterized as dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy.

Funder

Deanship of Scientific Research, King Saud University

Science and Technology Development Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00337C

Reference90 articles.

1. American Cancer Society , Special Section: Lung Cancer, https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2023/2023-cff-special-section-lung-cancer.pdf

2. Update of Incidence, Prevalence, Survival, and Initial Treatment in Patients With Non–Small Cell Lung Cancer in the US

3. State-of-the-art combination treatment strategies for advanced stage non–small cell lung cancer

4. Synergistic induction of apoptosis by sulindac and simvastatin in A549 human lung cancer cells via reactive oxygen species-dependent mitochondrial dysfunction

5. Hybrid Molecules with a Dual Mode of Action: Dream or Reality?