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Mammalian mitochondrial DNA replication and mechanisms of deletion formation

Published:2020-09-24 Issue:6 Volume:55 Page:509-524
ISSN:1040-9238
Container-title:Critical Reviews in Biochemistry and Molecular Biology
language:en
Short-container-title:Critical Reviews in Biochemistry and Molecular Biology

Author:

Falkenberg Maria¹^ORCID,Gustafsson Claes M.¹

Affiliation:

1. Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden

Funder

Swedish Research Council

Swedish Cancer Foundation

Knut and Alice Wallenberg Foundation

European Research Council

Swedish Government and the County Councils

Publisher

Informa UK Limited

Subject

Molecular Biology,Biochemistry

Link

https://www.tandfonline.com/doi/pdf/10.1080/10409238.2020.1818684

Reference130 articles.

1. Replication-transcription switch in human mitochondria

2. Human mitochondrial DNA is packaged with TFAM

3. A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL

4. Fractionation of mitochondrial RNA from HeLa cells by high-resolution electrophoresis under strongly denaturing conditions

5. Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

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2. Our current understanding of the biological impact of endometrial cancer mtDNA genome mutations and their potential use as a biomarker;Frontiers in Oncology;2024-06-27

3. A novel mutation of DNA2 regulates neuronal cell membrane potential and epileptogenesis;Cell Death Discovery;2024-05-27

4. Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications;Journal of Biological Chemistry;2024-04

5. Structural basis of how MGME1 processes DNA 5′ ends to maintain mitochondrial genome integrity;Nucleic Acids Research;2024-03-12

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