Conditionally active T cell engagers for the treatment of solid tumors: rationale and clinical development
Author:
Affiliation:
1. Maverick Therapeutics, Inc., a wholly owned subsidiary of Takeda Development Center Americas, Inc, Brisbane, CA, USA
Funder
No funding
Publisher
Informa UK Limited
Subject
Clinical Biochemistry,Drug Discovery,Pharmacology
Link
https://www.tandfonline.com/doi/pdf/10.1080/14712598.2022.2098674
Reference58 articles.
1. Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes.
2. Heteroantibody duplexes target cells for lysis by cytotoxic T lymphocytes.
3. Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody
4. Hybrid antibodies can target sites for attack by T cells
5. Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody
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