Altered bile acid metabolism in skin tissues in response to ionizing radiation: deoxycholic acid (DCA) as a novel treatment for radiogenic skin injury

Author:

Zhang Yining1,Yan Tao1,Mo Wei2,Song Bin1,Zhang Yuehua13,Geng Fenghao1,Hu Zhimin4,Yu Daojiang3,Zhang Shuyu1235ORCID

Affiliation:

1. Department of Radiation Medicine, Laboratory of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China

2. School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine, Soochow University, Suzhou, China

3. The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China

4. Key Laboratory of Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, China

5. NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Mianyang, China

Funder

National Natural Science Foundation of China

Young Talent Project of China National Nuclear Corporation

Scientific Fund for Distinguished Young Scholars in Sichuan Province

Publisher

Informa UK Limited

Subject

Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology

Reference57 articles.

1. Bile acids: regulation of apoptosis by ursodeoxycholic acid

2. Pathophysiology of irradiated skin and breast

3. The Metabolism of Chenodeoxycholic Acid to beta-Muricholic Acid in Rat Liver

4. Bile Acid Metabolism and Signaling

5. Radiation-induced gastrointestinal toxicity. Pathophysiology, approaches to treatment and prophylaxis;Classen J;Strahlenther Onkol,1998

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