R-TPI: rolling toxicity probability interval design to shorten the duration and maintain safety of phase I trials
Author:
Affiliation:
1. Laiya Consulting, Inc., Wilmette, Illinois, USA
2. Research Institute, NorthShore University HealthSystem, Evanston, Illinois, USA
3. Biostatistics Department, Juno Therapeutics, Seattle, Washington, USA
Publisher
Informa UK Limited
Subject
Pharmacology (medical),Pharmacology,Statistics and Probability
Link
https://www.tandfonline.com/doi/pdf/10.1080/10543406.2019.1577683
Reference19 articles.
1. Systematic comparison of the statistical operating characteristics of various Phase I oncology designs
2. Bayesian dose escalation in oncology with sharing of information between patient populations
3. Sequential Designs for Phase I Clinical Trials with Late-Onset Toxicities
4. Innovations for phase I dose-finding designs in pediatric oncology clinical trials
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