Optimal biological dose selection in dose-finding trials with model-assisted designs based on efficacy and toxicity: a simulation study-Reference-Cited by-同舟云学术

Optimal biological dose selection in dose-finding trials with model-assisted designs based on efficacy and toxicity: a simulation study

Published:2023-04-28 Issue: Volume: Page:1-15
ISSN:1054-3406
Container-title:Journal of Biopharmaceutical Statistics
language:en
Short-container-title:Journal of Biopharmaceutical Statistics

Author:

Yamaguchi Yusuke¹^ORCID,Takeda Kentaro¹^ORCID,Yoshida Satoshi²,Maruo Kazushi³^ORCID

Affiliation:

1. Astellas Pharma Global Development, Inc, Northbrook, Illinois, USA

2. Data Science, Astellas Pharma Inc, Tokyo, Japan

3. Department of Biostatistics, University of Tsukuba, Tsukuba, Japan

Funder

financial support

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Link

https://www.tandfonline.com/doi/pdf/10.1080/10543406.2023.2202259

Reference41 articles.

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2. Algorithm AS 206: Isotonic Regression in Two Independent Variables

3. U-Shaped Dose-Responses in Biology, Toxicology, and Public Health

4. Clinical efficacy of the optimal biological dose in early-phase trials of anti-cancer targeted therapies

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