Biotransformation of (−)-epicatechin, (+)-epicatechin, (−)-catechin, and (+)-catechin by intestinal bacteria involved in isoflavone metabolism

Abstract

Abstract Isoflavone-metabolizing bacteria, Adlercreutzia equolifaciens, Asaccharobacter celatus, Slackia equolifaciens, and Slackia isoflavoniconvertens catalyzed C-ring cleavage of (–)-epicatechin and (+)-catechin, (+)-epicatechin, and (–)-catechin in varying degrees. The cleaving abilities of (–)-epicatechin and (+)-catechin were enhanced by hydrogen, except (+)-catechin cleavage by S. equolifaciens, which was not accelerated. (−)-Catechin cleavage by Ad. equolifaciens was remarkably accelerated by hydrogen.