Isolation and identification of N6-isopentenyladenosine as the cytotoxic constituent of a marine sponge Oceanapia sp.-Reference-Cited by-同舟云学术

Isolation and identification of N6-isopentenyladenosine as the cytotoxic constituent of a marine sponge Oceanapia sp.

Published:2019-11-02 Issue:11 Volume:83 Page:1985-1988
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Nakamukai Shohei¹,Ise Yuji²,Ohtsuka Susumu³,Okada Shigeru¹,Matsunaga Shigeki¹

Affiliation:

1. Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

2. Center for Marine and Coastal Studies, Universiti Sains Malaysia, Penang, Malaysia

3. Takehara Marine Science Station, Hiroshima University, Takehara, Hiroshima, Japan

Abstract

ABSTRACT N 6-Isopentenyladenosine (i6A) was isolated from a marine sponge Oceanapia sp. as the major cytotoxic constituent along with N6-isopentenyladenosine 5ʹ-monophosphate (i6AP) which was inactive. The structures of i6A and i6AP were assigned by a combination of the analysis of NMR spectroscopy and mass spectrometry. This is the first isolation of i6A and i6AP from a marine sponge.

Funder

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/83/11/1985/36834284/bbb1985.pdf

Reference19 articles.

1. The discovery and development of marine compounds with pharmaceutical potential;Munro;J Biotechnol,1999

2. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin;Takai;FEBS Lett,1984

3. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin;Suganuma;Cancer Res,1990

4. Interactions of halichondrin B and eribulin with tubulin;Bai;J Chem Inf Model,2011

5. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol;Ter;Biochemistry,1996

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