Synthetic approach toward complexity of sialic acid-containing glycans

Author:

Ando Hiromune12

Affiliation:

1. Department of Applied Bioorganic Chemistry, Gifu University, Gifu, Japan

2. Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto

Abstract

Abstract The biological relevance of sialic acid-containing glycans (sialo-glycans) to various interactions at the cell surface has increased the demand for the supply of structurally defined sialo-glycans. Due to their unique structures, the stereoselective synthesis of glycosides of sialic acid is inherently difficult, which makes the synthetic approach to synthesize diverse and complex sialo-glycans far from successful. However, the gap between the chemical and natural synthesis of complex sialo-glycans is narrowing through the emergence of synthetic methods. This review highlights recent progress made in the synthesis of complex sialo-glycans via cutting-edge synthetic methods.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

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