Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94-Reference-Cited by-同舟云学术

Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94

Published:2020-06-02 Issue:6 Volume:84 Page:1303-1307
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kato Sho¹²,Motoyama Takayuki¹,Futamura Yushi¹,Uramoto Masakazu¹,Nogawa Toshihiko¹,Hayashi Toshiaki¹,Hirota Hiroshi¹,Tanaka Akira¹³,Takahashi-Ando Naoko³⁴,Kamakura Takashi⁵,Osada Hiroyuki¹²

Affiliation:

1. Chemical Biology Research Group, RIKEN CSRS, Wako, Saitama, Japan

2. Graduate School of Science and Engineering, Saitama University, Sakura, Saitama, Japan

3. Graduate School of Science and Engineering, Toyo University, Kawagoe, Saitama, Japan

4. Graduate School of Engineering, Toyo University, Kawagoe, Saitama, Japan

5. Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

Abstract

ABSTRACT We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97–94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.

Funder

JSPS KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/84/6/1303/36847798/bbb1303.pdf

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3. Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells;Yamaguchi;Angew Chem Int Ed Engl,2005