Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor-Reference-Cited by-同舟云学术

Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor

Published:2015-02-01 Issue:2 Volume:79 Page:239-241
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kim Jeonghyun¹,Montagne Kevin²,Ushida Takashi²,Furukawa Katsuko¹³

Affiliation:

1. Department of Mechanical Engineering, Graduate School of Engineering, University of Tokyo, Tokyo, Japan

2. Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, School of Medicine, University of Tokyo, Tokyo, Japan

3. Department of Bioengineering, Graduate School of Engineering, University of Tokyo, Tokyo, Japan

Abstract

Abstract In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Furthermore, we showed that loading hydrostatic pressure induced the upregulation of PKR, which is known to participate in mechanotransduction in various models.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/79/2/239/36807759/bbb0239.pdf

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