The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis-Reference-Cited by-同舟云学术

The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis

Published:2017-09-07 Issue:3 Volume:28 Page:530-541
ISSN:1439-7595
Container-title:Modern Rheumatology
language:en
Short-container-title:Modern Rheumatology

Author:

Kimura Hirotaka¹²,Matsuyama Yasushi³⁴,Araki Sachiko⁵,Koizumi Atsushi⁶,Kariya Yumi¹,Takasuga Shunsuke¹,Eguchi Satoshi¹,Nakanishi Hiroki²,Sasaki Junko¹,Sasaki Takehiko¹²

Affiliation:

1. Department of Medical Biology, Akita University Graduate School of Medicine, Akita, Japan;

2. Research Center for Biosignaling, Akita University, Akita, Japan;

3. Medical Educational Center, Jichi Medical University, Tochigi, Japan;

4. Department of Internal Medicine, Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan;

5. Department of Internal Medicine, Niizashiki Central General Hospital, Saitama, Japan;

6. Department of Urology, Akita University Graduate School of Medicine, Akita, Japan

Funder

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Rheumatology

Link

https://www.tandfonline.com/doi/pdf/10.1080/14397595.2017.1367116

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2. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

3. Antibodies Against Granule Proteins Activate Neutrophils In Vitro

4. Neutrophil Extracellular Traps Kill Bacteria

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