Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment-Reference-Cited by-同舟云学术

Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment

Published:2019-01-16 Issue:7 Volume:60 Page:1632-1643
ISSN:1042-8194
Container-title:Leukemia & Lymphoma
language:en
Short-container-title:Leukemia & Lymphoma

Author:

Shen Yandong¹²,Crassini Kyle¹,Sandhu Suneet¹,Fatima Narjis¹,Christopherson Richard I.²,Mulligan Stephen P.¹²,Best O. Giles¹²

Affiliation:

1. Northern Blood Research Centre, Kolling Institute, Royal North Shore Hospital, St Leonards, NSW, Australia;

2. School of Life and Environmental Sciences (SOLES), University of Sydney, Sydney, NSW, Australia

Publisher

Informa UK Limited

Subject

Cancer Research,Oncology,Hematology

Link

https://www.tandfonline.com/doi/pdf/10.1080/10428194.2018.1542148

Reference50 articles.

1. Growth Factors Can Protect B-Chronic Lymphocytic Leukaemia Cells Against Programmed Cell Death Without Stimulating Proliferation

2. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

3. Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

4. The CLL Cell Microenvironment

5. Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

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