Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?

Author:

Yu Chenglong1,Hodge Allison M23,Wong Ee Ming14,Joo Jihoon E56,Makalic Enes3,Schmidt Daniel F3,Buchanan Daniel D567,Severi Gianluca89,Hopper John L3,English Dallas R23,Giles Graham G123,Milne Roger L123,Southey Melissa C124,Dugué Pierre-Antoine123ORCID

Affiliation:

1. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia

2. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia

3. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia

4. Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia

5. Colorectal Oncogenomics Group, Department of Clinical Pathology, Melbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia

6. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia

7. Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia

8. Centre de Recherche en Epidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine Universités Paris-Saclay, Uvsq, Villejuif, France

9. Department of Statistics, Computer Science and Applications “G. Parenti”, University of Florence, Firenze, Italy

Funder

VicHealth and Cancer Council Victoria

Australian NHMRC

Cancer Council Victoria

NHMRC

Publisher

Informa UK Limited

Subject

Cancer Research,Molecular Biology

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