The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
Author:
Affiliation:
1. Department of Biology, University of Padova, Padova, Italy
2. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
Funder
Associazione Italiana per la Ricerca sul Cancro
European Molecular Biology Organization
Fondazione Telethon
National Cancer Institute
Publisher
Informa UK Limited
Subject
Cell Biology,Developmental Biology,Molecular Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/15384101.2018.1480216
Reference49 articles.
1. Single-stranded nucleic acids promote SAMHD1 complex formation
2. Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction
3. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction
4. SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity
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