The ribonuclease activity of SAMHD1 is required for HIV-1 restriction-Reference-Cited by-同舟云学术

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

Published:2014-07-20 Issue:8 Volume:20 Page:936-941
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Ryoo Jeongmin,Choi Jongsu,Oh Changhoon,Kim Sungchul,Seo Minji,Kim Seok-Young,Seo Daekwan,Kim Jongkyu,White Tommy E,Brandariz-Nuñez Alberto,Diaz-Griffero Felipe,Yun Cheol-Heui,Hollenbaugh Joseph A,Kim Baek,Baek Daehyun,Ahn Kwangseog

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.3626.pdf

Reference29 articles.

1. Laguette, N. et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474, 654–657 (2011).

2. Hrecka, K. et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474, 658–661 (2011).

3. Lahouassa, H. et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat. Immunol. 13, 223–228 (2012).

4. Baldauf, H.M. et al. SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Nat. Med. 18, 1682–1689 (2012).

5. St Gelais, C. et al. SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology 9, 105 (2012).

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