DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly-Reference-Cited by-同舟云学术

DNA-PKcs inhibition impairs HDAC6-mediated HSP90 chaperone function on Aurora A and enhances HDACs inhibitor-induced cell killing by increasing mitotic aberrant spindle assembly

Published:2021-01-06 Issue:2 Volume:20 Page:211-224
ISSN:1538-4101
Container-title:Cell Cycle
language:en
Short-container-title:Cell Cycle

Author:

Yu Lan¹,Lang Yue²,Guo Jiaming¹³,Cai Jianming³,Shang Zeng-Fu²,Chen Benjamin P.C¹

Affiliation:

1. Department of Radiation Oncology, Simmons Comprehensive Cancer Center at UT Southwestern Medical Center, Dallas, TX, USA

2. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China

3. Department of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, China

Funder

National Institutes of Health

National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Cell Biology,Developmental Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15384101.2020.1867790

Reference52 articles.

1. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks