Structural and functional insights into GSDMB isoforms complex roles in pathogenesis-Reference-Cited by-同舟云学术

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Structural and functional insights into GSDMB isoforms complex roles in pathogenesis

Published:2023-10-18 Issue:20 Volume:22 Page:2346-2359
ISSN:1538-4101
Container-title:Cell Cycle
language:en
Short-container-title:Cell Cycle

Author:

Colomo Sara¹²,Ros-Pardo David³,Oltra Sara S¹²⁴,Gomez-Puertas Paulino³,Sarrio David¹²,Moreno-Bueno Gema¹²⁴

Affiliation:

1. Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas ‘Sols-Morreale’ (IIBm-CISC), Madrid, Spain

2. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, Madrid, Spain

3. Grupo de modelado molecular, Centro de Biología Molecular Severo Ochoa, CBMSO (CSIC-UAM), Madrid, Spain

4. Laboratorio de Investigación Traslacional, Fundación MD Anderson Internacional (FMDA), Madrid, Spain

Funder

Instituto de Salud Carlos III

Publisher

Informa UK Limited

Subject

Cell Biology,Developmental Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15384101.2023.2287933

Reference53 articles.

1. Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

2. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

3. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

4. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

5. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

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