GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Author:
Affiliation:
1. Biozentrum University of Basel Basel Switzerland
2. Department of Biosystems Science and Engineering Eidgenössische Technische Hochschule (ETH) Zurich Basel Switzerland
3. Novartis Institutes for BioMedical Research Forum 1 Basel Switzerland
Funder
European Research Council
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Marie Curie Cancer Care
Publisher
EMBO
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience
Link
https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201694696
Reference45 articles.
1. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
2. Pyroptosis: host cell death and inflammation
3. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
4. Caspase target drives pyroptosis
5. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
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