Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC)

Author:

Schimanski Carl Christoph12ORCID,Kasper Stefan3,Hegewisch-Becker Susanna4,Schröder Jan5,Overkamp Friedrich6,Kullmann Frank7,Bechstein Wolf Otto8,Vöhringer Matthias9,Öllinger Robert10,Lordick Florian11,Heinemann Volker12,Geißler Michael13,Schulz-Abelius Armin14,Bernhard Helga15,Schön Michael R.16,Greil Richard17,Galle Peter1,Lang Hauke18ORCID,Schmidtmann Irene19,Moehler Markus1

Affiliation:

1. Medical Department 1, Johannes Gutenberg University, Mainz, Germany

2. Department of Gastroenterology, Hospital Darmstadt GmbH, Darmstadt, Germany

3. Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany

4. Hematological and Oncological Practice Eppendorf (HOPE), Practice for Oncology, Hamburg, Germany

5. Practice for Hematology and Oncology, Müllheim a.d.R., Germany

6. Oncologianova GmbH Recklinghausen, Recklinghausen, Germany

7. Department of Medicine I, Nordoberpfalz Clinics AG, Weiden i.d.O, Germany

8. Department of General and Visceral Surgery, Frankfurt University Hospital and Clinics, Frankfurt, Germany

9. Department of Hematology and Oncology, Robert Bosch Hospital, Stuttgart, Germany

10. Department of Surgery, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany

11. University Cancer Center Leipzig (UCCL), University Hospital Leipzig, Leipzig, Germany

12. Department of Medical Oncology and Comprehensive Cancer Center, University Hospital Grosshadern, Ludwig Maximilian University of Munich, Munich, Germany

13. Department of Internal Medicine, Oncology/Hematology, Gastroenterology, Hospital Esslingen GmbH, Esslingen, Germany

14. Department of Hematology and Oncology, Hospital Altenburger Land GmbH, Altenburg, Germany

15. Department of Hematology/Oncology, Klinikum Darmstadt GmbH, Darmstadt, Germany

16. Clinic of Visceral Surgery, Municipal Hospital Karlsruhe gGmbH, Karlsruhe, Germany

17. Department of Internal Medicine III, Paracelsus Medical University Salzburg, Salzburg Cancer Research Institute-CCCIT, Cancer Cluster, Salzburg, Austria

18. Department of General, Visceral and Transplantation Surgery, University Hospital of Mainz, Mainz, Germany

19. Institute for Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University Mainz, Mainz, Germany

Funder

Merck KGaA

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

Reference44 articles.

1. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

2. National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology. Colon cancer (Version 4). (2018). https://www.nccn.org. Accessed August 1st, 2020.

3. National Comprehensive Cancer Network (NCCN). NCCN Clinical Practice Guidelines in Oncology. Rectal cancer (Version 3). (2018). https://www.nccn.org. Accessed August 1st, 2020.

4. Rates and Patterns of Recurrence Following Curative Intent Surgery for Colorectal Liver Metastasis

5. Surgical resection of colorectal carcinoma metastases to the liver: A prognostic scoring system to improve case selection, based on 1568 patients

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