Neoadjuvant immune checkpoint blockade triggers persistent and systemic T reg activation which blunts therapeutic efficacy against metastatic spread of breast tumors

Author:

Blomberg Olga S.123,Kos Kevin123,Spagnuolo Lorenzo12,Isaeva Olga I.1,Garner Hannah12,Wellenstein Max D.123,Bakker Noor123,Duits Danique E.M.123,Kersten Kelly1,Klarenbeek Sjoerd4,Hau Cheei-Sing12,Kaldenbach Daphne12,Raeven Elisabeth A.M.12,Vrijland Kim12,Kok Marleen15,de Visser Karin E.123ORCID

Affiliation:

1. Division of Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands

2. Oncode Institute, Utrecht, The Netherlands

3. Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands

4. Experimental Animal Pathology Facility, Netherlands Cancer Institute, Amsterdam, Netherlands

5. Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands

Funder

Oncode Institute

KWF/Oncode consortium

NWO Oncology Graduate School Amsterdam Diamond Program

Swiss National Science Foundation

BMS-International Immuno-Oncology Network

F. Hoffmann-La Roche

Ministry of Health

Publisher

Informa UK Limited

Subject

Oncology,Immunology,Immunology and Allergy

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