Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers-Reference-Cited by-同舟云学术

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

Published:2020-04 Issue:4 Volume:26 Page:566-576
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Chalabi Myriam^ORCID,Fanchi Lorenzo F.,Dijkstra Krijn K.,Van den Berg José G.,Aalbers Arend G.,Sikorska Karolina,Lopez-Yurda Marta,Grootscholten Cecile,Beets Geerard L.^ORCID,Snaebjornsson Petur^ORCID,Maas Monique,Mertz Marjolijn,Veninga Vivien,Bounova Gergana,Broeks Annegien,Beets-Tan Regina G.,de Wijkerslooth Thomas R.,van Lent Anja U.,Marsman Hendrik A.,Nuijten Elvira,Kok Niels F.,Kuiper Maria,Verbeek Wieke H.,Kok Marleen^ORCID,Van Leerdam Monique E.,Schumacher Ton N.^ORCID,Voest Emile E.^ORCID,Haanen John B.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-020-0805-8.pdf

Reference47 articles.

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2. Overman, M. J. et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 18, 1182–1191 (2017).

3. Diaz, L. A. Jr. & Le, D. T. PD-1 blockade in tumors with mismatch-repair deficiency. NEJM 373, 1979 (2015).

4. Germano, G. et al. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Nature 552, 116–120 (2017).

5. Mandal, R. et al. Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response. Science 364, 485–491 (2019).

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