Long intervals between two doses of HPV vaccines and magnitude of the immune response: a post hoc analysis of two clinical trials

Author:

Gilca Vladimir12,Sauvageau Chantal12,Panicker Gitika3,De Serres Gaston12,Schiller John4,Ouakki Manale1,Unger Elisabeth R.3

Affiliation:

1. Division of Biological Risks, Quebec Public Health Institute, Quebec, Canada

2. Division of Infectious Disease and Immunity, Laval University Research Hospital Center, Quebec, Canada

3. Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

4. Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, USA

Publisher

Informa UK Limited

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference30 articles.

1. Merck Frosst Canada ltée. GARDASIL - Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine. Product Monograph. Kirkland: Merck Canada Inc. Feb 2015 p. 62. accessed on February 13, 2019 [En ligne]. Disponible: https://www.merck.ca/static/pdf/GARDASIL-PM_E.pdf

2. Merck Canada Inc. Highlights of prescribing information [On line] [accessed 2019 Feb 13] https://www.merck.com/product/usa/pi_circulars/g/gardasil_9/gardasil_9_pi.pdf

3. GlaxoSmithKline. CERVARIX® human papillomavirus vaccine types 16 and 18 (recombinant, AS04 adjuvanted) [On line]; 2008. [accessed 2019 Feb 13] https://ca.gsk.com/media/589880/cervarix.pdf

4. Plotkin SA, Orenstein WA, Offit PA. Vaccines. 6th edn ed. Philadelphia, USA: Saunders Elsevier; 2012. p. 1550.

5. Immunogenicity and HPV infection after one, two, and three doses of quadrivalent HPV vaccine in girls in India: a multicentre prospective cohort study

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