Discovery of selective farnesoid X receptor agonists for the treatment of hyperlipidemia from traditional Chinese medicine based on virtual screening and in vitro validation-Reference-Cited by-同舟云学术

Discovery of selective farnesoid X receptor agonists for the treatment of hyperlipidemia from traditional Chinese medicine based on virtual screening and in vitro validation

Published:2019-12-16 Issue:15 Volume:38 Page:4461-4470
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Chen Xi¹^ORCID,Lu Fang¹,Luo Ganggang¹,Ren Yue¹,Ma Jing¹,Zhang Yanling¹

Affiliation:

1. School of Chinese Material Medica, State Administration of Traditional Chinese Medicine, Research Center of TCM-Information Engineering, Beijing University of Chinese Medicine, Beijing, China

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2019.1695665

Reference33 articles.

1. Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand

2. Target Flexibility: An Emerging Consideration in Drug Discovery and Design†

3. A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia

4. Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR−/− and apoE−/− mice

5. Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor

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