Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand-Reference-Cited by-同舟云学术

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Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand

Published:2018-05 Issue: Volume:131 Page:17-31
ISSN:1043-6618
Container-title:Pharmacological Research
language:en
Short-container-title:Pharmacological Research

Author:

Carino Adriana^ORCID,Biagioli Michele,Marchianò Silvia,Scarpelli Paolo^ORCID,Zampella Angela,Limongelli Vittorio,Fiorucci Stefano^ORCID

Publisher

Elsevier BV

Subject

Pharmacology

Reference49 articles.

1. Bile acid-activated receptors, intestinal microbiota and the treatment of metabolic disorders;Fiorucci;Trends Mol. Med.,2015

2. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders;Fiorucci;Trends Pharmacol. Sci.,2009

3. Bile acids: natural ligands for an orphan nuclear receptor;Parks;Science,1999

4. General molecular biology and architecture of nuclear receptors;Pawlak;Curr. Top. Med. Chem.,2012

5. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis;Goodwin;Mol. Cell,2000

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