The importance of chain context in assessing small nucleotide variants in titin: in silico case study of the I10-I11 tandem and its arrhythmic right ventricular cardiomyopathy linked position T2580-Reference-Cited by-同舟云学术

The importance of chain context in assessing small nucleotide variants in titin: in silico case study of the I10-I11 tandem and its arrhythmic right ventricular cardiomyopathy linked position T2580

Published:2020-05-22 Issue:10 Volume:39 Page:3480-3490
ISSN:0739-1102
Container-title:Journal of Biomolecular Structure and Dynamics
language:en
Short-container-title:Journal of Biomolecular Structure and Dynamics

Author:

Fleming J. R.¹^ORCID,Rigden D. J.²,Mayans O.¹

Affiliation:

1. Department of Biology, University of Konstanz, Konstanz, Germany

2. Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK

Funder

EU Marie Sklodowska-Curie Individual Fellowship

British Heart Foundation

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/07391102.2020.1768148

Reference44 articles.

1. The effect of calcium binding on the unfolding force of mutated and healthy titin I10 domain: A steered molecular dynamics simulation study

2. GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers

3. Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac Disease Mechanism*

4. Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Walking with giants: The challenges of variant impact assessment in the giant sarcomeric protein titin;WIREs Mechanisms of Disease;2023-12-29

2. Molecular insights into titin’s A-band;Journal of Muscle Research and Cell Motility;2023-05-31

3. Interdomain Linker Effect on the Mechanical Stability of Ig Domains in Titin;International Journal of Molecular Sciences;2022-08-30

4. Pairwise sequence similarity mapping with PaSiMap: reclassification of immunoglobulin domains from titin as case study;2022-05-16

5. Pairwise sequence similarity mapping with PaSiMap: Reclassification of immunoglobulin domains from titin as case study;Computational and Structural Biotechnology Journal;2022